Unresolved Questions in Telephone Consulting

Unresolved questions in human copper pump mechanisms.

Copper (Cu) is an essential transition metal providing activity to key enzymes in the human body. To regulate the levels and avoid toxicity, cells have developed elaborate systems for loading these enzymes with Cu. Most Cu-dependent enzymes obtain the metal from the membrane-bound Cu pumps ATP7A/B in the Golgi network. ATP7A/B receives Cu from the cytoplasmic Cu chaperone Atox1 that acts as the...

Modern treatment of amyloidosis: unresolved questions.

During the past 10 to 15 years, there has been substantial progress in developing new treatments for the systemic amyloidoses. These advances have improved patient outcomes but have also raised new questions with direct clinical implications. For example, development of less intensive treatments for AL amyloidosis has made less certain the role of autologous stem cell transplantation, and new q...

Revisiting unresolved questions: land, food and agriculture

Binocular processing of motion: some unresolved questions.

The unresolved questions relating to binocular processing of motion include: Is the perceived speed of the motion in depth (MID) of an approaching object inversely proportional to the time to collision?; What visual information supports judgements of the direction of MID?; What is the relation between binocular and monocular processing in the perception of MID? We review whether the perception ...

Unresolved Questions in J/ψ Production and Propagation in Nuclei

In order to understand the J/ψ suppression arising from the possible occurrence of the quark-gluon plasma in high-energy heavy-ion collisions, it is necessary to have a comprehensive picture how the J/ψ and its precursors are produced, what their properties after production are, and how the J/ψ and its precursors propagate inside nuclear matter. There are unresolved questions in the description...